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KMID : 0939920110430040260
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대한암학회지
2011 Volume.43 No. 4 p.260 ~ p.263
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Fatal Ifosfamide-Induced Metabolic Encephalopathy in Patients with Recurrent Epithelial Ovarian Cancer: Report of Two Cases
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Shin You-Jung
Kim Ji-Young
Moon Jei-Won
You Rae-Mi
Park Jeong-Yeol
Nam Joo-Hyun
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Abstract
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Central nervous system (CNS) toxicity has been reported in approximately 10-30% of patients receiving intravenous infusions of ifosfamide. Encephalopathy is a rare but serious CNS adverse reaction in these patients, and although usually transient and reversible, may cause persistent neurological dysfunction or death. Clinical features range from fatigue and confusion to coma and death. Although methylene blue can be used to treat ifosfamide-induced neurotoxicity, including encephalopathy, its mechanism of action remains poorly defined. We describe here two patients with recurrent epithelial ovarian cancer who experienced fatal encephalopathy following ifosfamide/mesna treatment.
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KEYWORD
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Encephalopathy, Ovarian epithelial cancer, Ifosfamide, Mesna, Methylene blue
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